Lednicer, Daniel published the artcile4-Amino-4-arylcyclohexanones and their derivatives: a novel class of analgesics. 2. Modification of the carbonyl function, Quality Control of 18928-94-4, the publication is Journal of Medicinal Chemistry (1981), 24(4), 404-8, database is CAplus and MEDLINE.
The cyclohexanols I (R = H, alkyl, alkenyl, alkynyl, PhCH2, PhCH2CH2, etc.; R1 = H, Cl, Br, Me), prepared by the reduction of or addition of nucleophiles to the corresponding cyclohexanones, were separated into cis and trans isomers and tested for analgesic activity. The trans (OH and N) isomers were invariably more potent than the cis. I (R = PhCH2CH2) are among the most potent opioids reported to date; possibly the ring system may be providing an addnl. binding site for these compounds, and thus greatly enhance their affinity for the opioid receptor.
Journal of Medicinal Chemistry published new progress about 18928-94-4. 18928-94-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic cyclic hydrocarbon, name is (2-Bromoethyl)cyclopentane, and the molecular formula is C7H13Br, Quality Control of 18928-94-4.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary