Lange, Stefanie C. published the artcileEfficient and Tunable Three-Dimensional Functionalization of Fully Zwitterionic Antifouling Surface Coatings, SDS of cas: 55788-44-8, the publication is Langmuir (2016), 32(40), 10199-10205, database is CAplus and MEDLINE.
In order to enhance the sensitivity and selectivity of surface-based (bio)sensors, it is of crucial importance to diminish background signals that arise from the nonspecific binding of biomols., so-called biofouling. Zwitterionic polymer brushes have been shown to be excellent antifouling materials. However, for sensing purposes, antifouling does no suffice, but need to be combined with the possibility to efficiently modify the brush with recognition units. So far this has only been achieved at the expense of either antifouling properties or binding capacity. Herein the authors present a conceptually new approach by integrating both characteristics into a single, tailor-made monomer: a novel sulfobetaine-based zwitterionic monomer equipped with a clickable azide moiety. Copolymerization of this monomer with a well-established standard sulfobetaine monomer, results in highly antifouling surface coatings with a high, yet tunable amount of clickable groups present throughout the entire brush. Subsequent functionalization of the azido-brushes, via e.g. widely used strain-promoted alkyne azide click reactions yields fully zwitterionic 3D-functionalized coatings with a recognition unit of choice that can be tailored for any specific application. Here the authors show a proof-of-principle with biotin-functionalized brushes on Si3N4 that combine excellent antifouling properties with specific avidin binding from a protein mixture The signal-to-noise ratio is significantly improved over traditional chain end modification of sulfobetaine polymer brushes, even if the azide content is lowered to 1%, thus offering a viable approach for the development of significantly improved performance of biosensors on any surface.
Langmuir published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, SDS of cas: 55788-44-8.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary