Kamachi, Hiroaki published the artcileStructure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity, Synthetic Route of 111865-47-5, the publication is Bioorganic & Medicinal Chemistry (2013), 21(10), 2695-2702, database is CAplus and MEDLINE.
We have recently developed a simplified analog of aplysiatoxin (aplog-1) as an activator of protein kinase C (PKC) with anti-proliferative activity like bryostatin 1. To identify sites in aplog-1 that could be readily modified to optimize therapeutic performance and to develop a mol. probe for examining the analog’s mode of action, substituent effects on the phenol ring were systematically examined Whereas hydrophilic acetamido derivatives were less active than aplog-1 in inhibiting cancer cell growth and binding to PKCĪ“, introduction of hydrophobic bromine and iodine atoms enhanced both biol. activities. The anti-proliferative activity was found to correlate closely with mol. hydrophobicity, and maximal activity was observed at a log P value of 4.0-4.5. An induction test with Epstein-Barr virus early antigen demonstrated that these derivatives have less tumor-promoting activity in vitro than aplog-1 regardless of the hydrophobicity of their substituents. These results would facilitate rapid preparation of mol. probes to examine the mechanism of the unique biol. activities of aplog-1.
Bioorganic & Medicinal Chemistry published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Synthetic Route of 111865-47-5.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary