Ghiringhelli, Francesca published the artcileDirect β- and γ-C(sp3)-H Alkynylation of Free Carboxylic Acids, Computed Properties of 21101-63-3, the publication is Angewandte Chemie, International Edition (2020), 59(51), 23127-23131, database is CAplus and MEDLINE.
The authors report the identification of a novel class of ligands for palladium-catalyzed C(sp3)-H activation that enables the direct alkynylation of free carboxylic acid substrates. In contrast to previous synthetic methods, no introduction/removal of an exogenous directing group is required. A broad scope of acids including both α-quaternary and challenging α-non-quaternary can be used as substrates. Addnl., the alkynylation in the distal γ-position is reported. Finally, this study encompasses preliminary findings on an enantioselective variant of the title transformation as well as synthetic applications of the products obtained.
Angewandte Chemie, International Edition published new progress about 21101-63-3. 21101-63-3 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,sulfides,Benzyl bromide,Benzene, name is (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane, and the molecular formula is C8H6BrF3S, Computed Properties of 21101-63-3.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary