Eubanks, Lisa M. published the artcileIdentification of α2 Macroglobulin as a Major Serum Ghrelin Esterase, Application of 7-Bromohept-1-yne, the publication is Angewandte Chemie, International Edition (2011), 50(45), 10699-10702, S10699/1-S10699/23, database is CAplus and MEDLINE.
Ghrelin is an appetite-stimulating hormone secreted from endocrine cells in the stomach. Ghrelin is synthesized as a 117-residue polypeptide (preproghrelin) which undergoes proteolytic cleavage to produce the 94-residue proghrelin. Subsequent post-translational processing events include cleavage of proghrelin at residue Arg28 and octanoylation at the hydroxyl group of Ser3; these modifications generate the mature 28-residue ghrelin peptide. In serum, the inactivation of ghrelin is thought to occur primarily by deacylation of Ser3. In order to capture serum-based serine hydrolase enzymes that participate in the deacylation of circulating ghrelin, the present work describes the synthesis of a ghrelin-like “bait” mol. (probe 1) that contains a phosphonofluoridate warhead. The interaction of probe 1 with α2-macroglobulin (α2M) lead to addnl. studies which indicate that α2M possesses ghrelin esterase activity and plays an important role in ghrelin metabolism
Angewandte Chemie, International Edition published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C7H11Br, Application of 7-Bromohept-1-yne.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary