Barnych, Bogdan published the artcileDevelopment of potent inhibitors of the human microsomal epoxide hydrolase, Name: 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, the publication is European Journal of Medicinal Chemistry (2020), 112206, database is CAplus and MEDLINE.
Microsomal epoxide hydrolase (mEH) hydrolyzes a wide range of epoxide containing mols. Although involved in the metabolism of xenobiotics, recent studies associate mEH with the onset and development of certain disease conditions. This phenomenon is partially attributed to the significant role mEH plays in hydrolyzing endogenous lipid mediators, suggesting more complex and extensive physiol. functions. In order to obtain pharmacol. tools to further study the biol. and therapeutic potential of this enzyme target, we describe the development of highly potent 2-alkylthio acetamide inhibitors of the human mEH with IC50 values in the low nanomolar range. These are around 2 orders of magnitude more potent than previously obtained primary amine, amide and urea-based mEH inhibitors. Exptl. assay results and rationalization of binding through docking calculations of inhibitors to a mEH homol. model indicate that an amide connected to an alkyl side chain and a benzyl-thio function as key pharmacophore units.
European Journal of Medicinal Chemistry published new progress about 1997-80-4. 1997-80-4 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Benzene, name is 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, and the molecular formula is C9H8BrF3, Name: 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary