Month: December 2022

One-Pot Alkene Hydroboration/Palladium-Catalyzed Migratory Suzuki-Miyaura Cross-Coupling was written by Baumgartner, Yann;Baudoin, Olivier. And the article was included in ACS Catalysis in 2020.COA of Formula: C10H13BrO This article mentions the following:

Chain-walking is a powerful approach toward the functionalization of C-H bonds remote to a functional group. Whereas various Pd-catalyzed migratory cross-couplings have been developed in the past years, the design of an efficient migratory version of the popular Suzuki-Miyaura cross-coupling has remained elusive. The current article reports a one-pot procedure consisting of alkene hydroboration and migratory Suzuki-Miyaura coupling of the resulting alkylboronic acid intermediate. A high regioselectivity for the benzylic position of the initial alkene was achieved by using P(t-Bu)₂Me as the ligand and an ortho-substituted aryl electrophile. Regioconvergence from alkene positional and geometrical isomers and long-range migration were demonstrated. Mechanistic investigations indicated that the migration occurs through a partially reversible, nondissociative mechanism. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3COA of Formula: C10H13BrO).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.COA of Formula: C10H13BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Enantioselective allylation of imines catalyzed by newly developed (-)-β-pinene-based π-allylpalladium catalyst: an efficient synthesis of (R)-α-propylpiperonylamine and (R)-pipecolic acid was written by Fernandes, Rodney A.;Nallasivam, Jothi L.. And the article was included in Organic & Biomolecular Chemistry in 2012.Computed Properties of C23H26BrP This article mentions the following:

A newly developed π-allylpalladium with a (-)-β-pinene framework and an iso-Bu side chain catalyzed the enantioselective allylation of imines in good yields and enantioselectivities (20 examples, up to 98% ee). An efficient enantioselective synthesis of the (R)-α-Pr piperonylamine part of a human leukocyte elastase inhibitor and (R)-pipecolic acid have been achieved as a useful application of this methodol. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Computed Properties of C23H26BrP).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Computed Properties of C23H26BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nickel-Catalyzed N-Arylation of Diarylamines for Triarylamine Synthesis was written by Hu, Kunjun;Gao, Yunlong;Jin, Jian. And the article was included in Organometallics in 2022.Recommanded Product: 100189-84-2 This article mentions the following:

A practical Ni-catalyzed C-N cross-coupling reaction between diarylamines and aryl halides was developed using com. available NiCl₂(dppf) as the catalyst. This robust method can be efficiently applied to a variety of diarylamines which are privileged motifs in materials science, including phenoxazines, phenothiazines, carbazoles, diphenylamines, 9-10-dihydroacridines, 10,11-Dihydro-5H-dibenzo[b,f]azepines, 5H-dibenzo[b,f]azepines, and 9H-tribenzo[b,d,f]azepines. In the experiment, the researchers used many compounds, for example, 2,5-Dibromo-1,3-dimethylbenzene (cas: 100189-84-2Recommanded Product: 100189-84-2).

2,5-Dibromo-1,3-dimethylbenzene (cas: 100189-84-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: 100189-84-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Use of an additive scheme for calculating retention indexes in gas-liquid chromatography. 2. Possible quantitative calculation of the induction effect was written by Keiko, V. V.;Prokop’ev, B. V.;Kuz’menko, L. P.;Kalinina, N. A.;Bokova, G. N.. And the article was included in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1972.Recommanded Product: 1-Bromo-4-methoxybutane This article mentions the following:

The retention time data were analyzed for a wide range of ethers and halogenated aliphatic compounds The values were not found to be materially guided by interaction of functional groups present in terms of inductive effect substituent constant of the groups present. The inductive contribution can only account for about half the quadratic mean deviations of the exptl. data from the values calculated solely on the principle of additivity. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Recommanded Product: 1-Bromo-4-methoxybutane).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Recommanded Product: 1-Bromo-4-methoxybutane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of novel N-substituted thiazolidinediones (TZDs) as HDAC8 inhibitors: in-silico studies, synthesis, and biological evaluation was written by Upadhyay, Neha;Tilekar, Kalpana;Jansch, Niklas;Schweipert, Markus;Hess, Jessica D.;Henze Macias, Luca;Mrowka, Piotr;Aguilera, Renato J.;Choe, Jun-yong;Meyer-Almes, Franz-Josef;Ramaa, C. S.. And the article was included in Bioorganic Chemistry in 2020.Name: 3,4-Dibromoaniline This article mentions the following:

Among Class I and II HDACs, HDAC8 is one of the essential epigenetic players in cancer progression. Therefore, authors designed, synthesized, and purified novel compounds containing N-substituted thiazolidinediones I (Ar = C₆H₅, 2-FC₆H₄, pyridin-2-yl, etc.). Cell viability assay of all compounds on leukemic cell lines showed the cytotoxic potential of I (Ar = 2,3-FC₆H₃, 2-Cl,5CF₃C₆H₃, 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl, 4-MeC₆H₄, benzo[d]thiazol-2-yl, 3,4-BrC₆H₃). In-vitro screening of different HDACs isoforms revealed that I (Ar = benzo[d]thiazol-2-yl) was the most potent and selective inhibitor for HDAC8 (IC₅₀ – 9.3μM). Thermal shift anal. confirmed the binding of I (Ar = benzo[d]thiazol-2-yl) to HDAC8. In-vitro screening of I on the transport activity of GLUT1, 4, and 5 indicated that I (Ar = benzo[d]thiazol-2-yl) inhibited GLUT1 (IC50 – 28.2μM). Thiazolidinedione I (Ar = 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl) and I (Ar = benzo[d]thiazol-2-yl) induced apoptotic cell death in CEM cells (55.19% and 60.97% resp.) and I (Ar = benzo[d]thiazol-2-yl) was less cytotoxic on normal WBCs (CC₅₀ – 104.2μM) and human fibroblasts (HS27) (CC₅₀ – 105.0μM). Thus, among these, compound I (Ar = benzo[d]thiazol-2-yl) was most promising HDAC8 inhibitor and cytotoxic on leukemic cells. Thus, I (Ar = benzo[d]thiazol-2-yl) could serve as a lead for further development of optimized mols. with enhanced selectivity and potency. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Name: 3,4-Dibromoaniline).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Name: 3,4-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Triple condensation of aryl methyl ketones catalyzed by amine and trifluoroacetic acid: straightforward access to 1,3,5-triarylbenzenes under mild conditions was written by Zhang, Shao-Liang;Xue, Zhao-Feng;Gao, Ya-Ru;Mao, Shuai;Wang, Yong-Qiang. And the article was included in Tetrahedron Letters in 2012.Computed Properties of C24H15Br3 This article mentions the following:

An efficient triple condensation reaction of aryl Me ketones catalyzed by ethylenediamine and trifluoroacetic acid was reported. A broad scope of 1,3,5-triarylbenzenes was obtained in good to excellent yields. The reaction provides a novel and practical approach to access polycyclic aromatic hydrocarbons under mild conditions. In the experiment, the researchers used many compounds, for example, 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl (cas: 96761-85-2Computed Properties of C24H15Br3).

3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl (cas: 96761-85-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Computed Properties of C24H15Br3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rigid Rod Conjugated Polymers for Nonlinear Optics. 3. Intramolecular H Bond Effects on Poly(phenyleneethynylene) Chains was written by Moroni, M.;Le Moigne, J.;Pham, T. A.;Bigot, J.-Y.. And the article was included in Macromolecules in 1997.Recommanded Product: 2-Amino-5-bromo-4-fluorobenzoic acid This article mentions the following:

The synthesis and the X-ray and optical characterization of conjugated soluble poly(phenyleneethynylene)s, in which the planarity of the backbone has been improved by intramol. H bonds, are described. The solubility of the polymers was enhanced by increasing the number of alkyl chains on the aryl group. The electron d. on the Ph ring was also modified by the amino and ester groups, introducing electron-donor or electron-acceptor groups, which also increase the polarizability. The polymers have been synthesized by polycondensation using a palladium-catalyzed coupling reaction, between a bromoaryl and an ethynylaryl unit, with HBr elimination. This method allows the insertion of a triple bond between two Ph groups. It was initially used to obtain oligomers or high mol. weight polymers, having important nonlinear susceptibilities. The new polymers have been characterized by UV-visible and Raman spectroscopies, as well as nonlinear optical measurements of the third-order susceptibilities (χ⁽³⁾). These measurements show the influence of the H bonds between the aryl groups on the absorption wavelength. In addition, the nonlinear optical measurements show that the χ⁽³⁾ value of the pPY (6.8 × 10^-10 esu) is close to the highest values obtained in acetylenic polymers such as polydiacetylenes. In the experiment, the researchers used many compounds, for example, 2-Amino-5-bromo-4-fluorobenzoic acid (cas: 143945-65-7Recommanded Product: 2-Amino-5-bromo-4-fluorobenzoic acid).

2-Amino-5-bromo-4-fluorobenzoic acid (cas: 143945-65-7) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Recommanded Product: 2-Amino-5-bromo-4-fluorobenzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Palladium-catalyzed annulation reactions of methyl o-halobenzoates with azabicyclic alkenes: a general protocol for the construction of benzo[c]phenanthridine derivatives was written by Guo, Cui;Huang, Kanglun;Wang, Bo;Xie, Longguang;Xu, Xiaohua. And the article was included in RSC Advances in 2013.Recommanded Product: 653-92-9 This article mentions the following:

The annulation reaction of Me o-halobenzoates with azabicyclic alkenes proceeds efficiently to give the corresponding benzo[c]phenanthridine derivatives in good to excellent yields using a developed base-free methodol. based on our preliminary studies. Thirty-seven application examples validate the compatibility of the present strategy with different groups, particularly with the electron-deficient ones, that are difficult to access using other traditional methods. In addition, annulation reactions with non-sym. azabicyclic alkenes are achieved in high regioselectivity. In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9Recommanded Product: 653-92-9).

Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Recommanded Product: 653-92-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and Antioxidative Activity of N,N-Dialkyl-ω-[4-hydroxy(methoxy)aryl]alkylamines and Their N-Oxides was written by Dyubchenko, O. I.;Nikulina, V. V.;Terakh, E. I.;Prosenko, A. E.;Grigor’ev, I. A.. And the article was included in Russian Journal of Applied Chemistry in 2005.Name: 1-(3-Bromopropyl)-4-methoxybenzene This article mentions the following:

(Aminoalkyl)phenols of various structures were prepared by reactions of ω-[4-hydroxy(methoxy)aryl]haloalkanes with dialkylamines. The corresponding N-oxides were prepared by oxidation of (aminoalkyl)phenols with H₂O₂ and cumene hydroperoxide. The inhibiting activities of these compounds in a model reaction of thermal autoxidation of lard were compared. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Name: 1-(3-Bromopropyl)-4-methoxybenzene).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Name: 1-(3-Bromopropyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Electronic transport between Au surface and scanning tunnelling microscope tip via a multipodal cyclodextrin host-metallo-guest supramolecular system was written by Kylloenen, Lasse E. P.;Chinuswamy, Viswanathan;Maffeo, Davide;Kefalas, Evangelos T.;Haider, Johanna M.;Pikramenou, Zoe;Mavridis, Irene M.;Yannakopoulou, Konstantina;Glezos, Nikos. And the article was included in Journal of Physical Organic Chemistry in 2012.Related Products of 53784-83-1 This article mentions the following:

An elementary supramol. conducting system was constructed using a novel (±)-thioctic acid-functionalized β-cyclodextrin host deposited on a gold (Au) surface and an iridium-bearing guest mol. with biphenyl tails to insert specifically into the cyclodextrin cavity. The resulting supramol. system was used to investigate remote electron communication between the flat Au surface and the platinum (Pt)/iridium (Ir) tip of a scanning tunnelling microscope. The morphol. of the surfaces after successive deposition of host mols. followed by guest mols. was investigated. Formation of features of 2 nm size was shown on the Au surface functionalized with the supramol. system. I-V spectroscopic anal. of the tunnelling current through this supramol. layer revealed the relation between the effective barrier height and tunnelling distance. Thus, in the supramol. host-metallo-guest system, a small increase of conductance is observed, compared to the layer without the guest. This can be attributed to the presence of the Ir-guest, which eventually creates intermediate energy states between the Au substrate and the Pt/Ir tip. Copyright © 2011 John Wiley & Sons, Ltd. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Related Products of 53784-83-1).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Related Products of 53784-83-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary