Wang, Yipu published the artcileVisualizing Aβ deposits in live young AD model mice with a simple red/near-infrared-fluorescent AIEgen, Category: bromides-buliding-blocks, the publication is Science China: Chemistry (2022), 65(2), 339-352, database is CAplus.
Precise and early detection of β-amyloid (Aβ) deposits in situ and in real time is pivotal to the diagnosis and early intervention of Alzheimer’s disease (AD). Optical imaging stands out to be a promising technique for such a task; however, it still remains a big challenge, due to the lack of high-performance imaging contrast agent. Restricted by poor blood-brain barrier (BBB) penetrability, short-wavelength excitation and emission, as well as the aggregation-caused quenching effect, the widely used gold-standard probes cannot be used for early in-vivo imaging of Aβ deposits. Herein, we integrate the Aβ deposits-favored geometry, amphiphilic and zwitterionic mol. structure, extended D-π-A electronic structure, and 3D conformation into one mol., facilely establishing a simple and economic imaging contrast agent that enjoys high specificity and affinity to Aβ deposits, good BBB penetrability, bright red/near-IR fluorescence, low interference from autofluorescence, aggregation-induced emission (AIE) feature, high signal-to-noise ratio (SNR), and high contrast. In-vitro, ex-vivo, and in-vivo experiments with different strains of mice indicate that AIE-CNPy-AD holds the universality to Aβ deposits identification. Noteworthily, AIE-CNPy-AD is even able to precisely trace the small and sparsely-distributed Aβ deposits in AD model mice as young as 4-mo-old APP/PS1 mice, the youngest having Aβ deposits. Moreover, the present probe could clearly reveal the increase and enlargement of Aβ deposits as the mice grow. Therefore, AIE-CNPy-AD might be an ideal alternative for early AD diagnosis and highly reliable monitoring of AD progression.
Science China: Chemistry published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C15H12O6, Category: bromides-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary