Tsukamoto, Hirokazu published the artcileScalable Total Syntheses and Structure-Activity Relationships of Haouamines A, B, and Their Derivatives as Stable Formate Salts, Formula: C7H8BBrO3, the publication is Chemistry – A European Journal (2020), 26(55), 12528-12532, database is CAplus and MEDLINE.
Haouamines A, B, and their derivatives were synthesized via Suzuki-Miyaura coupling and three key cyclization reactions as follows: the newly developed palladium(0)-catalyzed arylative cyclization of phenylalanine-derived alkyne-aldehydes with 2-bromoarylboronic acid (an “anti-Wacker”-type cyclization); BF3·OEt2-promoted Friedel-Crafts-type cyclization of sym. electron-rich aromatic rings adjacent to a tertiary allylic alc. leading to the indeno-tetrahydropyridine skeleton; and (cyanomethyl)trimethylphosphonium iodide-mediated macrocyclization of amino alcs. to afford aza-paracyclophane precursors. The palladium-catalyzed reduction of mono- and di-triflate intermediates in the later stages enabled the alteration of both the position and number of hydroxyl groups on the C-ring. The instability of haouamine B was dramatically improved by salt formation with formic acid. An unambiguous evaluation of the cytotoxicity of the prepared haouamine derivative formates with and without hydroxyl groups at different positions on the C-ring indicated that the catechol structure in haouamine B produced weak cytotoxicity.
Chemistry – A European Journal published new progress about 89694-44-0. 89694-44-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 2-Bromo-5-methoxybenzene boronic acid, and the molecular formula is C9H8O4, Formula: C7H8BBrO3.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary