Kitagawara, Yumina published the artcileNovel bioactivation pathway of benzbromarone mediated by cytochrome P450, Application of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Drug Metabolism & Disposition (2015), 43(9), 1303-1306, database is CAplus and MEDLINE.
Benzbromarone (BBR) is a hepatotoxic drug, but the detailed mechanism of its toxicity remains unknown. We identified 2,6-dibromohydroquinone (DBH) and mono-debrominated catechol (2-ethyl-3-(3-bromo-4,5-dihydroxybenzoyl)benzofuran; CAT) as novel metabolites of BBR in rat and human liver microsomal systems by comparison with chem. synthesized authentic compounds, and we also elucidated that DBH is formed by cytochrome P 450 2C9 and that CAT is formed mainly by CYP1A1, 2D6, 2E1, and 3A4. Furthermore, CAT, DBH, and the oxidized form of DBH are highly cytotoxic in HepG2 compared with BBR. Taken together, our data demonstrate that DBH, a novel reactive metabolite, may be relevant to BBR-induced hepatotoxicity.
Drug Metabolism & Disposition published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Application of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary