Grote, Michaela published the artcileSyntheses of novel modified acyclic purine and pyrimidine nucleosides as potential substrates of herpes simplex virus type-1 thymidine kinase for monitoring gene expression, Safety of 5-(2-Bromoethyl)-2,2-dimethyl-1,3-dioxane, the publication is Canadian Journal of Chemistry (2004), 82(4), 513-523, database is CAplus.
Suicide gene therapy with the herpes simplex virus type-1 thymidine kinase gene (HSV-1 tk) is considered to be a promising approach to the treatment of cancer. Making use of the lower specificity of the viral enzyme compared to human thymidine kinase, the therapy involves the administration of antiviral agents (e.g., ganciclovir) as prodrugs to induce enzymic cell death in those cells that express the transferred gene. 18F-labeled derivatives have been described for monitoring location, duration, and magnitude of the viral kinase enzyme activity by positron emission tomog. (PET). Since an optimal radiotracer has not been developed, novel substances were synthesized for monitoring gene expression. A group of 13 nucleoside analogs were synthesized, among them N1-methyl-9-[(1,3-dihydroxy-2-propoxy)methyl]guanine and N1-methyl-9-[(4-hydroxy)-3-hydroxymethylbutyl]guanine as Me analogs of ganciclovir and penciclovir and their related fluoro compounds Further novel derivatives include N6-methyl-9-[(1,3-dihydroxy-2-propoxy)methyl]-, N6-methyl-9-[(4-hydroxy)-3-hydroxymethylbutyl]adenine, as well as the uracil derivatives 5-hydroxy-1-[(1,3-dihydroxy-2-propoxy)methyl]uracil, 6-methyl-1-[(1,3-dihydroxy-2-propoxy)-methyl]uracil, and its 3-fluoro-derivative
Canadian Journal of Chemistry published new progress about 97845-58-4. 97845-58-4 belongs to bromides-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Bromide, name is 5-(2-Bromoethyl)-2,2-dimethyl-1,3-dioxane, and the molecular formula is C8H15BrO2, Safety of 5-(2-Bromoethyl)-2,2-dimethyl-1,3-dioxane.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary