Abiru, Toichi published the artcileNucleosides and nucleotides. 107. 2-(Cycloalkylalkynyl)adenosines: adenosine A2 receptor agonists with potent antihypertensive effects, Safety of (2-Bromoethyl)cyclopentane, the publication is Journal of Medicinal Chemistry (1992), 35(12), 2253-60, database is CAplus and MEDLINE.
Adenosine receptor-binding profiles in rat brain tissues and antihypertensive effects in spontaneously hypertensive rats (SHR) of a series of 2-(cycloalkylalkynyl)adenosines, e.g. I [R = Ph, CH2CH2Ph, C(OH)Me2, cyclopentyl, cyclohexyl], and their congeners are described. MSBAR of this series of compounds I is discussed, focusing on the length of the alkynyl side chain, and bulkiness of the terminal cycloalkyl substituents in terms of binding activity and cardiovascular effects. I had a preferential affinity of for A2 receptors. Of these derivatives, 2-(3-cyclopenyl-1-propyn-1-yl)adenosine (II) exhibited the most selective affinity for A2 receptors. In the C-2 binding region of adenosine, compounds often have potent and/or selective A2 activity from introduction of an acetylenic group at the C-2 position followed by one methylene residue further followed by a hydrophobic substituent such as a cycloalkyl ring at the terminal position of the alkynyl side chain. I.v. injection of II up to 100 μg/kg had a potent hypotensive effect without a marked decrease in heart rate in anesthetized SHR. These compounds caused a marked bradycardia upon i.v. administration in anesthetized SHR. Oral administration of II (0.1-1 mg/kg) had a potent and long-lasting antihypertensive effect in conscious SHR.
Journal of Medicinal Chemistry published new progress about 18928-94-4. 18928-94-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic cyclic hydrocarbon, name is (2-Bromoethyl)cyclopentane, and the molecular formula is C7H13Br, Safety of (2-Bromoethyl)cyclopentane.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary