Parveen, Shagufta published the artcileSelective synthesis and comparative activity of olefinic isomers of 1,2-benzothiazine-1,1-dioxide carboxylates as aldose reductase inhibitors, Formula: C7H5Br2F, the publication is RSC Advances (2014), 4(40), 21134-21140, database is CAplus.
1,2-Benzothiazine-1,1-dioxides I (R1 = 2,4,5-F3, 4-Br-2-F; R2 = CH3) and II were selectively synthesized via the Wittig olefination reaction under various temperature conditions. At 40 °C, esters I with high Z-stereoselectivity (83-87%) were formed, while esters II formed preferentially with moderate to excellent regioselectivity at 100-120 °C (77-96%). The acid isomers I (R2 = H) and II (R2 = H), formed by acid hydrolysis of the corresponding esters, were found to inhibit aldose reductase in order of activity β,γ-unsaturated > Z-α,β-unsaturated > E-α,β-unsaturated isomers. The β,γ-unsaturated isomer II (R1 = 4-Br-2F; R2 = H) exhibited the most potent inhibition activity, with an IC50 value of 0.057 μM. This was further supported by docking studies.
RSC Advances published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Formula: C7H5Br2F.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary