Fox, Martin E. published the artcileN-Alkenyl nitrone dipolar cycloaddition routes to piperidines and indolizidines. Part 7. Hydroxylamine-alkyne cyclizations. Formation of cyclic nitrones and application to the synthesis of the proposed structure for (±)-acacialactam, Application of (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1994), 3379-95, database is CAplus.
The cyclization of alkynylhydroxylamines to give five-, six- and seven-membered cyclic nitrones is described. A concerted intramol. ene-like pathway is proposed for the addition of the N-O-H group across the triple bond. Using 3,7-dimethyl-3,4,5,6-tetrahydro-2H-azepine 1-oxide as the starting material, the seven-membered lactam structure proposed for the natural product acacialactam was prepared and was found to be incorrect. (E)-CH2:CHCMe(OH)CH2CH2CH:CMeCONH2 is proposed as the structure for acacialactam.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Application of (4-Bromobut-1-yn-1-yl)trimethylsilane.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary