Wang, Huan published the artcileSynthesis and Evaluation of 1,2,4-Triazolo[1,5-a]pyrimidines as Antibacterial Agents Against Enterococcus faecium, HPLC of Formula: 21101-63-3, the publication is Journal of Medicinal Chemistry (2015), 58(10), 4194-4203, database is CAplus and MEDLINE.
Rapid emergence of antibiotic resistance is one of the most challenging global public health concerns. In particular, vancomycin-resistant Enterococcus faecium infections have been increasing in frequency, representing 25% of enterococci infections in intensive care units. A novel class of 1,2,4-triazolo[1,5-a]pyrimidines, e.g., I [R1 = C6H4R’, 2-thienyl, 3-thienyl, 2-furyl, 2-pyrrolyl, 2-imiazolyl, 3-indolyl, 3-pyridyl, 2-methoxy-3-pyridyl, 4-pyridyl, cyclohexyl; R’ = i-Pr-4, H, Me-4, Et-4, i-Bu-4, OH-4, OMe-4, OH-3-OMe-4, (OMe)2-3,4, O(Pr-i)-4, OCF3-4, SMe-4, etc.], II [R1 = C6H4NMe2-4, R2 = OEt,NHMe, R3 = SCH2Ph; R1 = 2-thienyl, R2 = OEt, R3 = SCH2C6H4CO2H-4], III [R1 = C6H4NMe2-4, R3 = SCH2Ph; R1 = C6H4OMe-4, C6H4OEt-2, R3 = SCH2C6H4CO2H-4; R1 = C6H3(OMe)2-3,4, R3 = CH2C6H4F-4; R1 = C6H4Cl-4, R3 = SCH2-(2-naphthyl)],. IV [R1 = C6H4NMe2-4, R2 = H, R3 = SCH2Ph; R1 = C6H4Me-4, R2 = H, R3 = SCH2C6H4Me-2; R1 = C6H4Me-4, R2 = Me-2, Me2-2,4, R3 = SCH2C6H4Me-3; R1 = C6H4Et-4, R2 = H, Me-2, R3 = SCH2C6H4OMe-3; etc.], V [R3 = H, NH2, CO2Me, CO2Et, SMe, SCH2CONH2, SCH2CO2Et, SCH2CH2NHCO2CH2Ph, SCH2-(4-pyridyl), S(2-pyridyl), SCH2C6H4R”-4; R” = Me, OMe, SMe, CF3, OCF3, SCF3, NO2, CN, CO2H, CO2Me] and VI [R1 = 2-thienyl, R3 = H; R1 = C6H4CHMe2-4, C6H4CO2H-4, R3 = SCH2CH2NHCO2CH2Ph], active against E. faecium is reported herein. We used a three-component Biginelli-like heterocyclization reaction for the synthesis of a series of these derivatives based on reactions of aldehydes, β-dicarbonyl compounds, and 3-alkylthio-5-amino-1,2,4-triazoles. The resulting compounds were assayed for antimicrobial activity against the ESKAPE panel of bacteria, followed by investigation of their in vitro activities. These analyses identified a subset of 1,2,4-triazolo[1,5-a]pyrimidines that had good narrow-spectrum antibacterial activity against E. faecium and exhibited metabolic stability with low intrinsic clearance. Macromol. synthesis assays revealed cell-wall biosynthesis as the target of these antibiotics.
Journal of Medicinal Chemistry published new progress about 21101-63-3. 21101-63-3 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,sulfides,Benzyl bromide,Benzene, name is (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane, and the molecular formula is C8H5F3O3, HPLC of Formula: 21101-63-3.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary