Wang, Bing Hui published the artcileInhibition of eukaryote protein kinases by isoquinoline and oxazine alkaloids, SDS of cas: 518-67-2, the publication is Planta Medica (1997), 63(6), 494-498, database is CAplus and MEDLINE.
The aporphine isoquinoline alkaloid apomorphine is a potent inhibitor of the catalytic subunit (cAK) of rat liver cAMP-dependent protein kinase (PKA), myosin light chain kinase (MLCK), and Ca2+– and phospholipid-dependent protein kinase C (PKC) (IC50 values 1, 11, and 8 μM, resp.). However, a number of O-methylated analogs of apomorphine are inactive or poor inhibitors of cAK. The benzophenanthridine isoquinoline alkaloid sanguinarine is a potent inhibitor of cAK but is a relatively poor inhibitor of PKC (IC50 values 6 and 217 μM, resp.). However a number of methylated analogs of sanguinarine are inactive as cAK inhibitors. The aporphine isoquinoline alkaloids (+)-boldine and bulbocapnine are noncompetitive inhibitors of MLCK with respect to both peptide substrate and ATP. The inhibition of cAK, MLCK, and PKC by apomorphine and sanguinarine is competitive with respect to ATP as substrate. The oxazine alkaloids darrow red, nile blue A, and oxazine 170 are variously effective as inhibitors of cAK, MLCK, PKC, and CDPK (IC50 values 4-65 μM). Ca2+ binds to apomorphine and (+)-boldine which, together with nile blue A and oxazine 170, are potent inhibitors of calmodulin (CaM)-dependent MLCK (IC50 values 11, 12, 4, and 7 μM, resp.), and interact with dansyl-CaM.
Planta Medica published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C3H5BN2O2, SDS of cas: 518-67-2.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary