Sun, Jianwei’s team published research in Journal of the American Chemical Society in 127 | CAS: 69361-41-7

Journal of the American Chemical Society published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C6H5F4NO3S, COA of Formula: C7H13BrSi.

Sun, Jianwei published the artcileBronsted Acid-Promoted Cyclizations of 1-Siloxy-1,5-diynes, COA of Formula: C7H13BrSi, the publication is Journal of the American Chemical Society (2005), 127(39), 13512-13513, database is CAplus and MEDLINE.

The 1st HNTf2-promoted 5-endo-dig cyclizations of 1-siloxy-1,5-diynes was developed, which proceed with concomitant formation of C-Hal bonds as a result of halide abstraction from a halocarbon by the intermediate alkenyl cation. E.g., reaction of RCH2CCCH2CH2CCOTIPS (OTIPS = triisopropylsilanolato, R = n-C7H15) with HNTf2/CH2Cl2 at -78° and allowed to warm to room temperature to give 70% yield of 2-(1-chloro-2-R-ethylidene)cyclopentanone. This process is enabled by a chemoselective activation of the more electron-rich siloxy alkyne moiety of the diyne cyclization precursor and represents an efficient and highly diastereoselective method for assembly of a range of β-halo enones.

Journal of the American Chemical Society published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C6H5F4NO3S, COA of Formula: C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary