Lv, You published the artcileDesign, synthesis and fungicidal activity of 3,4-dichloroisothiazolocoumarin-containing strobilurins, SDS of cas: 401-55-8, the publication is Molecular Diversity (2022), 26(2), 951-961, database is CAplus and MEDLINE.
Twenty-one novel 3,4-dichloroisothiazolocoumarin-containing strobilurins I (R1 = H, F, Cl, Me, Et; R2 = H, 6-Me, 8-Me, 8-Cl), II were rationally designed and synthesized. Preliminary bioassay showed that compounds I (R1 = H, R2 = 8-Cl (III); R1 = Cl, R2 = 6-Me; R1 = Me, R2 = 6-Me) exhibited over 80% inhibitory rate against Sclerotinia sclerotiorum at 50μg/mL, compound III exhibited good activity against S. sclerotiorum with median effective concentration (EC50) of 4.08μ/mL, while the pos. control coumoxystrobin showed EC50 of 1.00μg/mL. In addition, compound I (R1 = H, R2 = 6-Me) showed better fungicidal activity with a lower EC50 value of 7.65μg/mL against Botrytis cinerea than that of pos. control trifloxystrobin with its EC50 value of 21.96μg/mL. In this study, it was indicated that 3,4-dichloroisothiazolocoumarin-containing strobilurins I, II were promising fungicide lead deserved for further study.
Molecular Diversity published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, SDS of cas: 401-55-8.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary