Kim, Heejin published the artcileIntegrated One-Flow Synthesis of Heterocyclic Thioquinazolinones through Serial Microreactions with Two Organolithium Intermediates, Name: (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane, the publication is Angewandte Chemie, International Edition (2015), 54(6), 1877-1880, database is CAplus and MEDLINE.
An integrated microfluidic synthesis of a biol. active thioquinazolinone library was presented. Generation of o-lithiophenyl isothiocyanate and subsequent reaction with aryl isocyanates was optimized by controlling the residence time in the microreactor to 16 ms at room temperature S-Benzylic thioquinazolinone derivatives I (R1 = H, F, OMe, NO2, Cl, R2 = H; R1 = H, R2 = F, Cl, OCF3, SCF3) were synthesized within 10 s in high yields (75-98 %) at room temperature These three-step reactions involved two organolithium intermediates, an isothiocyanate-functionalized aryllithium intermediate, and a subsequent lithium thiolate intermediate. The gram-scale synthesis of a multifunctionalized thioquinazolinone in the microfluidic device with a high yield (91 %) and productivity (1.25 g in 5 min) was also described.
Angewandte Chemie, International Edition published new progress about 21101-63-3. 21101-63-3 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,sulfides,Benzyl bromide,Benzene, name is (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane, and the molecular formula is C8H6BrF3S, Name: (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary