Luan, Yu-Yong published the artcileThree-Component Ruthenium-Catalyzed meta-C-H Alkylation of Phenol Derivatives, Synthetic Route of 401-55-8, the publication is Organic Letters (2022), 24(5), 1136-1140, database is CAplus and MEDLINE.
Herein, synthesis of phenyl-(pyrimidinyloxyphenyl)butanoates I [R1 = H, Me, Cl, etc.; R2 = H, Me, F, etc; R3 = Me, F; R4 = Ph, 4-FC6H4, 4-BrC6H4, etc.; R2 = R3 = Me, F; R5 = OEt, piperidin-1-yl, N(n-Bu)2] via three-component ruthenium catalyzed C-H alkylation of phenoxypyrimidines and vinylbenzene and ethyl-bromo-difluoroacetates/alkyl bromides was reported. This strategy exhibited good substrates suitability and functional group tolerance with various phenol derivatives, which provided a synthetic potential drug approach. Mechanistic studies showed that a radical process might be involved in this process. In addition, the meta alkylated phenol was obtained by further removal of the directing group.
Organic Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Synthetic Route of 401-55-8.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary