Belyaeva, T. N. published the artcileSanguinarine cytotoxicity for transformed mouse fibroblast L-cells in culture, sensitive and resistant to ethidium bromide, as compared to that of some other DNA-complexing agents, Safety of Dimidium bromide, the publication is Tsitologiya (1989), 31(11), 1363-8, database is CAplus.
A natural DNA intercalator, the benzo[c]phenanthridine alkaloid sanguinarine, is more toxic to mouse transformed fibroblast L-cells in culture than the synthetic DNA intercalator ethidium bromide (EtB) and the alkaloid berberine. Dimidium bromide is also an inhibitor of L-cell growth. In assay conditions, growth of L-cells is stopped by 1.5 x 10-5M sanguinarine. Lebr-625 cells, resistant to 25 μg EtB/mL, have sanguinarine sensitivity close to that of L-cells, but Lebr-625 cells are resistant to dimidium bromide. Sanguinarine is more toxic to L-cells in culture than the anticancer drug cis-Pt(NH3)2Cl2. trans-Pt(NH3)2Cl2 is less toxic to these cells. The strong toxicity of sanguinarine for L- and Lebr-625 cells in culture, as compared to other DNA-complexing drugs, seems to be associated with the wide range of potential cell targets for sanguinarine. Besides the inhibition of nucleic acid metabolism reactions, characteristic of DNA intercalators, and disruption of mitochondrial ATP synthesis, also characteristic of organic heterocyclic cationic DNA intercalators, sanguinarine can modify the SH groups of enzymes including SH-sensitive membrane-bound Na+, K+-ATPase of cerebral cortex and Ca2+-ATPase of skeletal muscle sarcoplasmic reticulum.
Tsitologiya published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Safety of Dimidium bromide.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary