Small molecule inhibitors of anthrax lethal factor toxin was written by Williams, John D.;Khan, Atiyya R.;Cardinale, Steven C.;Butler, Michelle M.;Bowlin, Terry L.;Peet, Norton P.. And the article was included in Bioorganic & Medicinal Chemistry in 2014.Synthetic Route of C10H11BrO3 The following contents are mentioned in the article:
This manuscript describes the preparation of new small mol. inhibitors of Bacillus anthracis lethal factor. The authors’ starting point was the sym., bis-quinolinyl compound (I) (NSC 12155). Optimization of one half of this mol. led to new LF inhibitors that were desymmetrized to afford more drug-like compounds This study involved multiple reactions and reactants, such as 3-(4-Bromo-2-methoxyphenyl)propanoic acid (cas: 1261675-06-2Synthetic Route of C10H11BrO3).
3-(4-Bromo-2-methoxyphenyl)propanoic acid (cas: 1261675-06-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Synthetic Route of C10H11BrO3
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary