An Indirect Synthetic Approach toward Conformationally Constrained 20-Membered Unclosed Cryptands via Late-Stage Installation of Intraannular Substituents was written by Jurczak, Janusz;Sobczuk, Adam;Dabrowa, Kajetan;Lindner, Marcin;Niedbala, Patryk. And the article was included in Journal of Organic Chemistry.Related Products of 80480-15-5 The following contents are mentioned in the article:
A new protocol for PTC-mediated O-alkylation of the intraannular position of 20-membered unclosed cryptands (UCs) is reported. In contrast to the classical, “direct” strategy, which requires functionalization of the lariat arm at the beginning of synthesis, this “indirect” approach enables the late-stage introduction of various benzylic substituents after an unfavorable macrocyclization step (11 examples, yields up to 98%). Notably, this method permits preparation of, previously inaccessible, crowded UCs bearing a 1-acetylpyrene substituent and a dimer joined by p-xylene linker. This study involved multiple reactions and reactants, such as 2-Bromo-1-(pyren-1-yl)ethanone (cas: 80480-15-5Related Products of 80480-15-5).
2-Bromo-1-(pyren-1-yl)ethanone (cas: 80480-15-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Related Products of 80480-15-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary