Base-Promoted Domino Reaction of 5-Substituted 2-Nitrosophenols with Bromomethyl Aryl Ketones: A Transition-Metal-Free Approach to 2-Aroylbenzoxazoles was written by Aljaar, Nayyef;Malakar, Chandi C.;Conrad, Juergen;Beifuss, Uwe. And the article was included in Journal of Organic Chemistry in 2015.Computed Properties of C18H11BrO The following contents are mentioned in the article:
The reaction of 5-substituted 2-nitrosophenols with bromomethyl aryl ketones and related compounds employing K2CO3 as a base in refluxing THF and DMF at 80 °C, resp., delivers 2-aroylbenzoxazoles in a single step with yields up to 85%. The new method involves an intermol. nucleophilic substitution followed by intramol. 1,2-addition and elimination. It allows an efficient and practical access to 2-aroylbenzoxazoles under transition-metal-free conditions. This study involved multiple reactions and reactants, such as 2-Bromo-1-(pyren-1-yl)ethanone (cas: 80480-15-5Computed Properties of C18H11BrO).
2-Bromo-1-(pyren-1-yl)ethanone (cas: 80480-15-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Computed Properties of C18H11BrO
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary