Ford, E. J. H. published the artcileCellular damage and changes in biliary excretion in a liver lesion of cattle, HPLC of Formula: 518-67-2, the publication is Journal of Pathology and Bacteriology (1962), 39-48, database is CAplus and MEDLINE.
Liver lesions, produced in adult cattle only, by parenteral administration of dimidium bromide can be used to assess a number of tests of hepatic dysfunction. Symptoms of early histol. changes, as detected by liver biopsies, first appeared 30-40 days after injection, and were reflected by marked increases in the serum levels of glutamic-oxalacetic transaminase, lactic dehydrogenase, isocitric dehydrogenase, and glutamic dehydrogenase. The level of glutamic-pyruvic transaminase was unchanged. Significant changes in serum enzyme levels occur even when histol. demonstrable damage is slight. These serum enzyme levels are sensitive indicators of early and mild hepatocellular damage. The later stages of hepatic lesion (40-50 days after injection) are accompanied by a fall in the rate of Bromsulphalein excretion. The phylloerythrin retention which was observed is likely to have been the underlying cause of the photosensitization observed in the original dimidium intoxication in Africa.
Journal of Pathology and Bacteriology published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, HPLC of Formula: 518-67-2.
Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary