Tanaka, Shinji published the artcileSystematic asymmetric analog synthesis of fluspidine, a σ1 receptor ligand, to improve ligand affinity, COA of Formula: C8H7BrO3, the main research area is fluspidine systematic asym preparation sigma receptor ligand.
Herein, fluspidine analogs I (R1 = H, 5-F, 6-Cl, 6-MeO, etc.; R2 = Ph, 3-FC6H4, 4-MeOC6H4, etc.; R3 = CH2F, CH2Cl, CH2Br, CH2I, COOH) were systematically synthesized and screened to improve the ligand affinity. To design the modified ligand analogs, a docking simulation of the protein-ligand complex structure was examined By using the developed synthetic strategy involving asym. catalytic 1,4-reduction of α,β-unsaturated carboxylic esters catalyzed by a chiral cobalt complex, 20 candidates of modified fluspidines were synthesized. The structure-activity relationships showed the development of a hybridized modified fluspidine. In addition, the inhibitory rate could be improved from 45% to 71%. This result demonstrated the importance of the development of a new synthetic method toward improving the ligand performance by providing a series of analogs.
Tetrahedron Letters published new progress about Drug metabolism. 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, COA of Formula: C8H7BrO3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary