Neelam, Uday Kumar published the artcileMetathesis approach to the formal synthesis of aliskiren, SDS of cas: 172900-69-5, the main research area is aliskiren Tekturna Rasilez renin inhibitor antihypertensive preparation enantioselective synthesis.
A formal synthesis of aliskiren by employing Grubbs second generation catalyst in a cross olefin metathesis, iron(III)-catalyzed vinylation and biocatalysis (enzyme catalysis) by using PLE is disclosed. The title compounds thus formed included (αS,γS,δS,ζS)-δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)benzeneoctanamide (Aliskiren) (I) and Aliskiren hemifumarate. The synthesis of the target compound was achieved by a convergent synthesis strategy. A reaction of (3S,5S)-5-[(1S,3S)-1-azido-3-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-4-methylpentyl]dihydro-3-(1-methylethyl)-2(3H)-furanone with 3-amino-2,2-dimethylpropanamide gave an azide precursor for I, i.e., (αS,γS,δS,ζS)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-δ-azido-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)benzeneoctanamide.
Chemistry & Biology Interface published new progress about Amidation. 172900-69-5 belongs to class bromides-buliding-blocks, name is 2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene, and the molecular formula is C17H27BrO3, SDS of cas: 172900-69-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary