Das, Soumen published the artcileSynthesis and biodistribution studies of 99mTc labeled fatty acid derivatives prepared via “”Click approach”” for potential use in cardiac imaging, SDS of cas: 56523-59-2, the main research area is technetium 99m fatty acid derivative preparation cardiac imaging; 99mTc carbonyl core; click chemistry; fatty acid; myocardial imaging.
123I-Iodophenylpentadecanoic acid (IPPA) is a metabolic agent used in nuclear medicine for diagnosis of myocardial defects. Efforts are underway worldwide to develop a 99mTc substitute of the above radiopharmaceutical for the aforementioned application. Herein, we report synthesis and biodistribution studies of 99mTc labeled fatty acids (8, 11, and 15 carbons) obtained via “”click chem.”” for its potential use in myocardial imaging. ω-Bromo fatty acids (8C/11C/15C) were synthetically modified at bromo terminal to introduce a heterocyclic triazole with glycine sidearm in a five step procedure. Modified fatty acids were subsequently radiolabeled with preformed [99mTc(CO)3]+ synthon to yield the desired fatty acid complexes which were evaluated in Swiss mice. All the radiolabeled complexes were obtained with radiochem. purities >80%, as characterized by HPLC. Biodistribution studies of all three complexes in Swiss mice showed myocardial uptake of ∼6-9% ID/g at 2 min post-injection, close to*I-IPPA (∼9% ID/g). Complexes exhibited significant retention in the myocardium up to 30 min (∼1% ID/g) but were lower to the standard agent (∼7% ID/g). Similar uptake of activity in myocardium for the newly synthesized complexes in comparison to 125I-IPPA along with favorable in vivo pharmacokinetics merits potential for the present “”click”” design of complexes for myocardial imaging.
Journal of Labelled Compounds and Radiopharmaceuticals published new progress about Heart disease. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, SDS of cas: 56523-59-2.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary