Carson, J. R. published the artcile2-Ethynylbenzenealkanamines. A new class of calcium entry blockers, Recommanded Product: 1-Bromo-4-fluoro-2-methylbenzene, the main research area is acetylenic benzenealkanamine calcium blocker; amine araliph calcium blocker; araliph amine antihypertensive vasodilator.
A series of 2-[aryl(alkyl)ethynyl]benzenealkanamines was synthesized. The compounds exhibit antihypertensive activity in spontaneously hypertensive rats and coronary vasodilator activity with minimal neg. inotropic activity in the Langendorff guinea pig heart in vitro. They exert their activity by inhibition of Ca2+ influx across cell membranes. Optimal activity is found among the N-(arylethyl)-5-methoxy-α-methyl-2-(phenylethynyl)benzeneethanamines and -propanamines, e.g., I.
Journal of Medicinal Chemistry published new progress about Angina pectoris. 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Recommanded Product: 1-Bromo-4-fluoro-2-methylbenzene.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary