Baumgarth, Manfred published the artcileA concise and efficient synthesis of [2-methyl-5-methylsulfonyl-4-(pyrrol-1-yl)benzoyl]guanidinium methanesulfonate (eniporide), Computed Properties of 452-63-1, the main research area is eniporide preparation.
A new synthesis of the benzoylguanidine-type Na+/H+ antiporter inhibitor eniporide is described. Starting from 2-bromo-5-fluorotoluene, aromatic substituents were introduced by methanesulfonylation, Pd-catalyzed carboxylation with CO, and halogen-pyrrole exchange. Guanidine acylation was performed using Mukaiyama’s procedure.
European Journal of Organic Chemistry published new progress about eniporide preparation. 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Computed Properties of 452-63-1.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary