Payard, Pierre-Adrien published the artcileTaming Nickel-Catalyzed Suzuki-Miyaura Coupling: A Mechanistic Focus on Boron-to-Nickel Transmetalation, Application In Synthesis of 452-63-1, the main research area is transmetalation mechanism nickel catalyzed Suzuki Miyaura coupling.
The mechanism of boron-to-nickel transmetalation, the key step of the nickel-catalyzed Suzuki-Miyaura (S-M) coupling, was examined both exptl. and theor. Dinuclear μ-hydroxo-bridged complexes formed by reaction of trans-[ArNi(PR3)2X] with hydroxide are not directly involved in transmetalation, but they rather act as a resting state for the catalyst. The base/boronic acid ratio is the crucial parameter, as it modulates the extent of formation of these dinuclear species and thus tunes the catalytic activity. These findings explain some limitations encountered in practical applications of nickel-catalyzed S-M couplings and suggest how to tailor the exptl. conditions in order to overcome these difficulties.
ACS Catalysis published new progress about Activation enthalpy. 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Application In Synthesis of 452-63-1.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary