Mueller, Ralf published the artcileLong Hydrocarbon Chain Ether Diols and Ether Diacids That Favorably Alter Lipid Disorders in Vivo, Safety of 1-Bromo-3-(3-bromopropoxy)propane, the main research area is hydrocarbon ether diol diacid lipid structure activity relationship antiobesity.
Long hydrocarbon chain ethers with bis-terminal hydroxyl or carboxyl groups have been synthesized and evaluated for their potential to favorably alter lipid disorders including metabolic syndrome. Compounds were assessed for their effects on the de novo incorporation of radiolabeled acetate into lipids in primary cultures of rat hepatocytes as well as for their effects on lipid and glycemic variables in female obese Zucker fatty rats following 1 and 2 wk of daily oral administration. The most active compounds were found to be sym. with four to five methylene groups separating the central ether functionality and the gem di-Me or methyl/aryl substituents. Biol. activity was found to be greatest for tetramethyl-substituted ether diols, while bis(arylmethyl) derivatives, diethers , and di-Ph ethers were the least active. For the most biol. active compound 28, we observed as much as a 346% increase in serum HDL-cholesterol and a 71% reduction in serum triglycerides at the highest dose administered (100 mg/kg) after 2 wk of treatment. For one compound we observed a 69% reduction in non-HDL-cholesterol, accompanied by a 131% increase in HDL-cholesterol and an 84% reduction in serum triglycerides under the same treatment conditions.
Journal of Medicinal Chemistry published new progress about Antiobesity agents. 58929-72-9 belongs to class bromides-buliding-blocks, name is 1-Bromo-3-(3-bromopropoxy)propane, and the molecular formula is C6H12Br2O, Safety of 1-Bromo-3-(3-bromopropoxy)propane.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary