Wisniewski, John A. published the artcileStructure-Based Design of 1,4-Dibenzoylpiperazines as β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction Inhibitors, Formula: C6H4BrNO3, the main research area is dibenzoylpiperazine preparation beta catenin BCL9 protein interaction inhibitor antitumor; B-cell lymphoma 9; Wnt signaling; inhibitor; protein−protein interactions; selectivity; β-Catenin.
A small-mol. inhibitor with a 1,4-dibenzoylpiperazine scaffold was designed to match the critical binding elements in the β-catenin/B-cell lymphoma 9 (BCL9) protein-protein interaction interface. Inhibitor optimization led to a potent inhibitor that can disrupt the β-catenin/BCL9 interaction and exhibit 98-fold selectivity over the β-catenin/cadherin interaction. The binding mode of new inhibitors was characterized by structure-activity relationships and site-directed mutagenesis studies. Cell-based studies demonstrated that this series of inhibitors can selectively suppress canonical Wnt signaling and inhibit growth of Wnt/β-catenin-dependent cancer cells.
ACS Medicinal Chemistry Letters published new progress about Antiproliferative agents. 41668-13-7 belongs to class bromides-buliding-blocks, name is 5-Bromo-6-hydroxynicotinic acid, and the molecular formula is C6H4BrNO3, Formula: C6H4BrNO3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary