Provera, Stefano published the artcileApplication of LC-NMR and HR-NMR to the characterization of biphenyl impurities in the synthetic route development for vestipitant, a novel NK1 antagonist, Quality Control of 452-63-1, the main research area is LC NMR biphenyl impurity vestipitant NK1 HPLC.
Vestipitant is a novel NK1 antagonist currently under investigation for the treatment of CNS disorders and emesis. The first synthetic step comprised a Grignard synthesis. An impurity was identified and initially expected to be a sym. biphenyl. This paper reports the work to synthesize the supposed structure and the spectroscopic analyses (LC-NMR and HR-NMR) to correctly identify the real structure and understand the chem. pathway of the impurity.
Journal of Pharmaceutical and Biomedical Analysis published new progress about High-resolution NMR spectroscopy. 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Quality Control of 452-63-1.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary