DeVries, Vern G. published the artcileHypolipidemic alkoxybenzoic acids, Application In Synthesis of 56523-59-2, the main research area is hypolipidemic alkoxybenzoic acid derivative; benzoic acid alkoxy derivative hypolipidemic.
A series of ∼90 p-alkoxybenzoic acids (I) with aromatic ring substituents or modified alkyl or unsaturated chains (R1), prepared by alkylation of the appropriate hydroxybenzoate ester followed by saponification, was screened in rats for serum-sterol and triglyceride lowering activity. Alkyl chain substituents such as chloro and oximino enhanced activity, while azido, thiol, and some alkylthio groups resulted in retention of activity. Some alkylthio substituents on the alkyl chain and aryl ring substituents abolished sterol-lowering activity. The effect of alkyl chain branching was variable, while unsaturation had no adverse effect on activity except when located near either end of the chain.
Journal of Medicinal Chemistry published new progress about Anticholesteremic agents. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Application In Synthesis of 56523-59-2.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary