Campeau, Louis-Charles published the artcilePalladium-Catalyzed Direct Arylation of Azine and Azole N-Oxides: Reaction Development, Scope and Applications in Synthesis, Recommanded Product: 1-Bromo-4-fluoro-2-methylbenzene, the main research area is azine azole oxide aryl halide palladium catalyst regioselective arylation.
Palladium-catalyzed direct arylation reactions were described with a broad range of azine and azole N-oxides. In addition to aspects of functional group compatibility, issues of regioselectivity were explored when nonsym. azine N-oxides were used. In these cases, both the choice of ligand and the nature of the azine substituents played important roles in determining the regioisomeric distribution. When azole N-oxides were employed, preferential reaction was observed for arylation at C2, which occurred under very mild conditions. Subsequent reactions were observed to occur at C5 followed by arylation at C4. The potential utility of this methodol. was illustrated by its use in the synthesis of a potent sodium channel inhibitor I and a Tie2 Tyrosine Kinase inhibitor II.
Journal of the American Chemical Society published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Recommanded Product: 1-Bromo-4-fluoro-2-methylbenzene.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary