Bugday, Nesrin published the artcileC-H Bond activation of 2-isobutylthiazole at C5 position catalysed by Pd-N-heterocyclic carbene complexes, Application of 1-Bromo-4-fluoro-2-methylbenzene, the main research area is aryl thiazole preparation regioselective; thiazole aryl bromide arylation palladium NHC complex catalyst.
A highly efficient and effective protocol was developed for the synthesis of C5-(hetero)arylated 2-isobutylthiazole derivatives I [Ar = Ph, 4-MeC6H4, 1-naphthyl, etc.]. Four different palladium N-heterocyclic carbene (Pd-NHCs) complexes [Pd(μ-Cl)Cl(SIMes)]2, (LCl2Pd-SIMes) (L = PPh3; L = Py; L = 3-CHO-Py) were synthesized and used for the first time as a catalysts in direct C-H arylation reaction of 2-isobutylthiazole at C5 position. Utilizations of these catalytic systems, the arylation of 2-isobutylthiazole with substituted (hetero)aryl bromides efficiently proceeded at low catalyst loading (1 mol%) and without any additives such as PivOH under argon or aerobic conditions at 120°C in a short time. Different substituted (hetero)aryl bromides, even some deactivated or highly sterically hindered (hetero)arylbromides, with a wide range of functional groups were successfully utilized under the optimum reaction conditions. In all cases, the C5 arylated 2-isobutylthiazoles were obtained in moderate to excellent yields.
Journal of Organometallic Chemistry published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Application of 1-Bromo-4-fluoro-2-methylbenzene.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary