Cruz, Cole L. published the artcileNickel-catalyzed reductive coupling of unactivated alkyl bromides and aliphatic aldehydes, Formula: C14H20BBrO3, the main research area is aliphatic aldehyde alkyl bromide reductive coupling nickel catalyst; silyl secondary alc preparation.
A mild, convenient coupling of aliphatic aldehydes e.g., BnCH2CHO and unactivated alkyl bromides e.g., Br(CH2)3C(O)OEt has been developed. The catalytic system features the use of a common Ni(II) precatalyst and a readily available bioxazoline ligand and affords silyl-protected secondary alcs. e.g., BnCH2CH(OTES)(CH2)3C(O)OEt. The reaction is operationally simple, utilizes Mn as a stoichiometric reductant, and tolerates a wide range of functional groups. The use of 1,5-hexadiene as an additive is an important reaction parameter that provides significant benefits in yield optimizations. Initial mechanistic experiments support a mechanism featuring an alpha-silyloxy Ni species that undergoes formal oxidative addition to the alkyl bromide via a reductive cross-coupling pathway.
Chemical Science published new progress about Aliphatic aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 913836-27-8 belongs to class bromides-buliding-blocks, name is 2-(4-(2-Bromoethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C14H20BBrO3, Formula: C14H20BBrO3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary