Liu, Tongchao published the artcileStereoselective and Regioselective Preparation of C-Pentopyranosides and Formal Synthesis of Omarigliptin, SDS of cas: 452-63-1, the main research area is synthon omarigliptin regioselective ring opening epoxide pentopyranoside preparation aminoglycoside; regioselective ring opening epoxide pentopyranoside omarigliptin preparation arabinose aminoglycoside.
A readily available intermediate obtained from D-arabinose was identified as a versatile starting material for the stereoselective synthesis of C-pentopyranosides in one pot. For two of the C-pentopyranosides, subsequent epoxide ring formation and a regioselective opening process was proven to be a robust approach to 3-deoxy C-pentopyranosides in two to four steps. A key intermediate used in the preparation of omarigliptin was obtained in four steps. Most of the conversions were high-yielding and proceeded with high selectivities on a multigram scale.
European Journal of Organic Chemistry published new progress about Ring opening, regioselective. 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, SDS of cas: 452-63-1.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary