Johnson, Kirsten F. published the artcileRhodium-Catalyzed, Enantioselective Hydroacylation of ortho-Allylbenzaldehydes, Safety of 1-Bromo-4-fluoro-2-methylbenzene, the main research area is rhodium catalyzed enantioselective hydroacylation allylbenzaldehyde; naphthalenone dihydro enantioselective synthesis.
The development of a rhodium catalyst for endo- and enantioselective hydroacylation of ortho-allylbenzaldehydes is reported. A catalyst generated in situ from [Rh(COD)Cl]2, (R)-DTBM-SEGPHOS, and NaBARF promotes the desired hydroacylation reactions and minimizes the formation of byproducts from competitive alkene isomerization and ene/dehydration pathways [e.g., 2-methallylbenzaldehyde → (R)-I (85%, 98% ee)]. These rhodium-catalyzed processes generate the 3,4-dihydronaphthalen-1(2H)-one products in moderate-to-high yields (49-91%) with excellent enantioselectivities (96-99% ee).
Organic Letters published new progress about Chiral ligands Role: CAT (Catalyst Use), USES (Uses). 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Safety of 1-Bromo-4-fluoro-2-methylbenzene.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary