In 2022,Zhao, Yuan; Liu, Ningning; Zhong, Shiping; Wen, Ziwei; Wang, Tao published an article in Organic Letters. The title of the article was 《A Central-to-Axial Chirality Conversion Strategy for the Synthesis of C-N Axially Chiral N-Arylpyrroles》.Recommanded Product: 7073-94-1 The author mentioned the following in the article:
A central-to-axial chirality conversion strategy is used for the construction of C-N axially chiral N-arylpyrroles I (R = H, 4-Me, naphthalen-1-yl, thiophen-2-yl, etc.; R1 = Br, I, Me, etc.; R2 = H, Me; R2R3 = phenyl) via a gold(I)-catalyzed 5-endo-dig cyclization/dehydration cascade from amino acid derivatives RCH(NH2)C(O)OH. The reaction exhibits high efficiency on the central-to-axial chirality conversion. D. functional theory calculations suggest that the stereospecificity during the central-to-axial chirality conversion lies in the stability of the conformations of the amino alc. and the corresponding low barrier transition state. After reading the article, we found that the author used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Recommanded Product: 7073-94-1)
1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. Recommanded Product: 7073-94-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary