Synthetic Route of C7H5BrO2In 2019 ,《Catalyst-Free Approach for Hydroboration of Carboxylic Acids under Mild Conditions》 appeared in ACS Omega. The author of the article were Xu, Xiaojuan; Yan, Dandan; Zhu, Zhangye; Kang, Zihan; Yao, Yingming; Shen, Qi; Xue, Mingqiang. The article conveys some information:
Aryl and alkyl carboxylic acids underwent hydroboration with pinacolborane under solvent-free conditions or in THF to yield primary alkyl pinacolborate esters. Seven of the borate esters were hydrolyzed to the corresponding primary alcs. in 90-93% yields with silica in MeOH. Benzoic acid was reduced under solvent-free conditions to yield benzyl pinacol borate in 98% yield on 15 mmol scale. After reading the article, we found that the author used 4-Bromobenzoic acid(cas: 586-76-5Synthetic Route of C7H5BrO2)
4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Synthetic Route of C7H5BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary