In 2022,Trunks, Thomas M.; Babra, Jasraj Singh; Westwood, James; Smith, Christopher D. published an article in SynOpen. The title of the article was 《A Homocoupling Approach to the Key Dione of CyMe 4-BTPhen-Vital Ligands for Nuclear Clean-Up by the SANEX Process》.Safety of Ethyl 3-bromopropanoate The author mentioned the following in the article:
The synthesis of the CyMe4 fragment beginning from readily available hydroxypivalic acid. It featured a cobalt-catalyzed homocoupling of a neopentyl bromide to provided the key bisester precursor, thereby avoiding the requirement for tech. challenging low-temperature LDA-mediated aldol chemistries. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-bromopropanoate(cas: 539-74-2Safety of Ethyl 3-bromopropanoate)
Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Safety of Ethyl 3-bromopropanoate Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary