The author of 《Divergent Synthesis of Isoquinolone and Isocoumarin Derivatives by the Annulation of Benzoic Acid with N-Vinyl Amide》 were Sun, Rui; Yang, Xiao; Li, Qianggen; Xu, Ke; Tang, Juan; Zheng, Xueli; Yuan, Maolin; Fu, Haiyan; Li, Ruixiang; Chen, Hua. And the article was published in Organic Letters in 2019. Formula: C7H5BrO2 The author mentioned the following in the article:
A simple and efficient method for the synthesis of isoquinolone and isocoumarin derivatives is reported. The method for the first time provides a one-step divergent synthesis of important isoquinolone and isocoumarin skeletons from benzoic acid by switching the coupling partners. In addition, a reliable mechanism has been proposed on the basis of exptl. investigations, including kinetic isotope effect experiments, 13C labeling experiments, time-tracking experiments, and competitive experiments, as well as DFT calculation studies. The results came from multiple reactions, including the reaction of 4-Bromobenzoic acid(cas: 586-76-5Formula: C7H5BrO2)
4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Formula: C7H5BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary