In 2022,Nair, Jay B.; Hakes, Linda; Yazar-Klosinski, Berra; Paisner, Kathryn published an article in ACS Omega. The title of the article was 《Fully Validated, Multi-Kilogram cGMP Synthesis of MDMA》.Recommanded Product: 5-Bromobenzo[d][1,3]dioxole The author mentioned the following in the article:
MDMA is increasingly used in clin. research, but no cGMP process has yet been reported. We describe here the first fully validated cGMP synthesis of up to 5 kg (≈30 000 patient doses) of MDMA in a four-step process beginning with a noncontrolled starting material. The overall yield was acceptable (41-53%, over four steps), and the chem. purity of the final product was excellent, exceeding 99.9% of the peak area by HPLC in each of the four validation trials. The availability of cGMP-compliant MDMA will facilitate ongoing clin. trials and provide for future therapeutic use, if encouraging results lead to FDA approval. The results came from multiple reactions, including the reaction of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Recommanded Product: 5-Bromobenzo[d][1,3]dioxole)
Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Recommanded Product: 5-Bromobenzo[d][1,3]dioxole
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary