《Palladium-Catalyzed Intermolecular trans-Selective Carbofunctionalization of Internal Alkynes to Highly Functionalized Alkenes》 was written by Lv, Weiwei; Liu, Shihan; Chen, Yanhui; Wen, Si; Lan, Yu; Cheng, Guolin. Formula: C9H11Br And the article was included in ACS Catalysis in 2020. The article conveys some information:
A palladium/DPEphos-catalyzed intermol. trans-selective carbofunctionalization of internal alkynes was established herein. This method proceeds through a formal anti-carbopalladation, forming trans-alkenyl palladium species, which was trapped by aryl boronic acids to provide all-carbon tetrasubstituted alkenes in 32-92% yields. The trans-selective arylsilylation/remote C-H silylation and hydroarylation/remote C-H borylation of internal alkynes were also achieved by using hexamethyldisilane and bis(pinacolato)diboron as trapping reagents, resp. The reaction features good regio- and stereoselectivity and high functional group tolerance. A preliminary mechanistic study and DFT calculations show that a cis to trans isomerization of cis-alkenyl palladium species was involved in this transformation. In addition to this study using 1-Bromo-2-isopropylbenzene, there are many other studies that have used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Formula: C9H11Br) was used in this study.
1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Formula: C9H11Br
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary