The author of 《Acylation of 25-hydroxyprotopanaxatriol with aromatic acids increases cytotoxicity》 were Lv, Liyan; Lu, Jincai; Zhang, Hongyu; Wang, Xude; Su, Guangyue; Piao, Huri; Zhao, Yuqing. And the article was published in Fitoterapia in 2019. Product Details of 586-76-5 The author mentioned the following in the article:
20(R)-25-hydroxyprotopanaxadiol (25-OH-PPD) is a natural compound showing a variety of anti-tumor effects. In an attempt to discover a new anti-cancer compound with higher antitumor activities, we designed and synthesized a series of 25-OH-PPD derivatives The cytotoxicity assay of these derivatives towards MCF-7, A549, U87, HO-8901, Hela cancer cell lines and normal IOSE144 cell lines were tested by MTT assay. Results showed that compared with compound 25-OH-PPD, acylated derivatives I [R = 4-ClC6H4, 2-FC6H4, 2,4-F2C6H3, 2-O2NC6H4, 3,5-(O2N)2C6H3] showed strong anticancer activity, and all compounds showed low toxicity or no toxicity for normal cells. In particular, compound I (R = 2,4-F2C6H3) (II) exhibited the best anti-tumor activity in all cancer cell lines (MCF-7, A549, U87, HO-8901, and Hela) with IC50 values of 5.04μM, 1.36μM, 3.24μM, 3.47μM, 4.57μM, resp. Among the five cell lines, all the compounds showed strong inhibition on A549 cells. Further studies showed that II significantly inhibited the proliferation of A549 cells by inducing apoptosis. Our results indicate that II is a potential anticancer inhibitor and provides a theor. basis for further research. In addition to this study using 4-Bromobenzoic acid, there are many other studies that have used 4-Bromobenzoic acid(cas: 586-76-5Product Details of 586-76-5) was used in this study.
4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Product Details of 586-76-5 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary