Quality Control of EthylbromofluoroacetateOn March 18, 2022, Lu, Dengfu; Li, Yadong; Wang, Peng; Wang, Zijie; Yang, Daoyi; Gong, Yuefa published an article in ACS Catalysis. The article was 《Cu-Catalyzed C(sp3)-N Coupling and Alkene Carboamination Enabled by Ligand-Promoted Selective Hydrazine Transfer to Alkyl Radicals》. The article mentions the following:
In this work, di-tert-Bu hydrazodiformate was found to be a unique effective amination reagent in Cu-catalyzed C(sp3)-N bond formation reactions that involve alkyl radical intermediates. This method was applicable to both electron-deficient and electron-rich radicals, and were able to achieve the direct C-N coupling of activated bromides, as well as the carboamination of general alkenes based on this chem. Mechanistic studies suggested that the hydrazodiformate forms a reducing dinuclear complex with Cu and the ligand which, upon 1e-oxidation, turns into an open-shell species with the major spin d. on N atoms. With the assistance of a ligand, this species can selectively deliver the hydrazine moiety onto an alkyl radical (prior to halide transfer), leading to the formation of a C(sp3)-N bond. The products obtained with this amination method could be easily deprotected to afford alkyl hydrazines and further derived to primary amines or N-heterocycles. In the experiment, the researchers used many compounds, for example, Ethylbromofluoroacetate(cas: 401-55-8Quality Control of Ethylbromofluoroacetate)
Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Quality Control of Ethylbromofluoroacetate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary