Application of 586-76-5In 2020 ,《Palladium-Catalyzed N-Acylation of Tertiary Amines by Carboxylic Acids: A Method for the Synthesis of Amides》 was published in Organic Letters. The article was written by Li, Zhaohui; Liu, Long; Xu, Kaiqiang; Huang, Tianzeng; Li, Xinyi; Song, Bin; Chen, Tieqiao. The article contains the following contents:
A palladium-catalyzed N-acylation of tertiary amines by carboxylic acids was achieved through C-N cleavage. This reaction showed a wide substrate scope. Both aromatic and aliphatic acids served well as the acylating reagents and coupled with tertiary amines to gave the corresponding amides RC(O)N(R1)2 [R = n-pentyl, Ph, 2-naphthyl, etc.; R1 = Me, Et, n-Pr] in good to excellent yields. With the strategy, bioactive carboxylic acids were also efficiently modified, highlighting the synthetic value of the process in organic synthesis. In the experiment, the researchers used 4-Bromobenzoic acid(cas: 586-76-5Application of 586-76-5)
4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Application of 586-76-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary