Safety of Methyl 3-bromopropanoateIn 2022 ,《Inhibiting Erastin-Induced Ferroptotic Cell Death by Purine-Based Chelators》 appeared in ChemBioChem. The author of the article were Joshi, Saurabh; Agarwal, Saloni; Panjla, Apurva; Valiyaveettil, Suresh; Ganesh, Subramaniam; Verma, Sandeep. The article conveys some information:
Ferroptosis is a cell death event caused by increased lipid peroxidation leading to iron-dependent oxidative stress and is associated with a wide variety of diseases. In recent years, ferroptosis inhibition has emerged as a novel strategy to target different pathologies. Here, we report the synthesis of two purine derivatives, 1 and 2, for iron chelation strategy and evaluate their potency to inhibit erastin-induced ferroptosis. Both compounds showed efficient iron chelation in solution as well as in cellular environment. The crystal structure of the purine derivatives with iron demonstrated a 2 : 1 (ligand to metal center) stoichiometry for iron and purine derivative complexation. The synthesized compounds also decrease the reactive oxygen species concentration in cell cultures. Compound 2 showed better potency towards the prevention of ferroptotic cell death as compared to com. available iron chelator in the erastin-induced ferroptosis cell culture model. Such purine analogs are potential functional scaffolds for the development of target mols. for ferroptosis inhibition. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-bromopropanoate(cas: 3395-91-3Safety of Methyl 3-bromopropanoate)
Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Safety of Methyl 3-bromopropanoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary